US 10,456,399 B2
Method for treating cancer patients with severe renal impairmentGeneral
US 10,456,399 B2
Method for treating cancer patients with severe renal impairment
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Rei Tsang Shiao
Art Unit:
1629 Organic Chemistry
Inventors:
Kenichiro YOSHIDA
Assignee:
Priority:
02/05/16
Filed:
08/03/18
Granted:
10/29/19
Expiration:
02/05/36
Abstract
A method for treating cancer in patients with creatinine clearance of 15 mL/min or more and less than 30 mL/min, including dividing a combination drug containing α,α,α-trifluorothymidine (FTD) and 5-chloro-6-[(2-iminopyrrolidine-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride in a molar ratio of 1:0.5, in a dose of 30 to 50 mg/m2/day as FTD-equivalent, into two to four times a day, and orally administering it to the patient.
Cooperative Patent Classification (CPC)
A61A61P35/00A61K31/7072A61P