US 10,596,278 B2
Stable, concentrated radionuclide complex solutionsGeneral
US 10,596,278 B2
Stable, concentrated radionuclide complex solutions
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Michael G. Hartley
Art Unit:
1618 Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
Agent:
Lian Ouyang
Inventors:
Francesco de Palo; Lorenza Fugazza; Donato Barbato; Maurizio Mariani; Daniela Chicco; Giovanni Tesoriere; Clementina Brambati
Assignee:
Priority:
07/25/18
Filed:
10/30/18
Granted:
03/24/20
Expiration:
07/25/38
Abstract
The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
Cooperative Patent Classification (CPC)
A61A61K9/0019A61K