US 10,610,675 B2
SYSTEMS AND METHODS FOR DELIVERY OF A THERAPEUTIC AGENTGeneral
US 10,610,675 B2
SYSTEMS AND METHODS FOR DELIVERY OF A THERAPEUTIC AGENT
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Albert M Navarro
Art Unit:
1645 Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
Inventors:
Hanson Gifford; Mark E. Deem
Assignee:
Priority:
07/21/06
Filed:
10/22/19
Granted:
04/07/20
Expiration:
07/22/25
Abstract
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
Cooperative Patent Classification (CPC)
A61A61M2210/1035A61B2018/00434A61N2007/003A61K2300/00A61P27/02A61MY02A50/30Y02AC12Y304/24069C12Y