METHODS FOR ANALYZING NUCLEIC ACIDS FROM SINGLE CELLS

Aspects of the present invention include analyzing nucleic acids from single cells using methods that include using tagged polynucleotides containing multiplex identifier sequences.

Methods for analyzing nucleic acids from single cells

BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING

Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor -Recombinant DNA-technology-Processes for the isolation, preparation or purification of DNA or RNA -Isolating an individual clone by screening libraries-Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags

MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA 

Reactions involving modified oligonucleotides, nucleic acids, or nucleotides-Modifications characterised by-incorporating/generating a new priming site

MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS ; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

Reactions involving modified oligonucleotides, nucleic acids, or nucleotides-Modifications characterised by-incorporating a promoter sequence

Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such compositions-involving nucleic acids-Nucleic acid amplification reactions-Polymerase chain reaction [PCR]

Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such compositions-involving nucleic acids-Nucleic acid amplification reactions-using modified primers or templates-Ligating adaptors

Nucleic acid detection characterized by the use of physical, structural and functional properties-the label being a nucleic acid

Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such compositions-involving nucleic acids-Methods for sequencing-involving nucleic acid arrays, e.g. sequencing by hybridisation

Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such compositions-involving nucleic acids-Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay 

Reactions involving modified oligonucleotides, nucleic acids, or nucleotides-Modifications characterised by-incorporating target specific and non-target specific sites

Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides-Massive parallel sequencing

Reactions characterised by the reaction format or use of a specific feature-the purpose or use of-Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis

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