US 10,759,779 B2
Crystalline form of orexin receptor antagonist, processes for preparation thereof and use thereofGeneral
US 10,759,779 B2
Crystalline form of orexin receptor antagonist, processes for preparation thereof and use thereof
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Paul V Ward
Art Unit:
1624 Organic Chemistry
Agent:
Inventors:
Minhua Chen; Xiaoyu Zhang; Yanfeng Zhang; Chunxiang Huang
Assignee:
Priority:
08/01/17
Filed:
01/30/20
Granted:
09/01/20
Expiration:
07/31/38
Abstract
The present disclosure provides a novel crystalline form of Lemborexant and processes for preparation thereof. Pharmaceutical composition containing Lemborexant, and use of Lemborexant for preparing orexin receptor antagonist drug, and use of Lemborexant for preparing drugs treating insomnia and irregular sleep-wake rhythm disorder are also provided. The crystalline form of the present disclosure have one or more improved properties compared with crystalline forms of prior arts, and has significant values for future drug optimization and development.
Cooperative Patent Classification (CPC)
A61A61P25/20A61K31/506A61PC07D401/12C07B2200/13C07D