US 10,835,515 B2 | CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM

US 10,835,515 B2

CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM

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US 10,835,515 B2

CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM

Tech Center:

1600 Biotechnology and Organic Chemistry

Examiner:

Kamal A Saeed

Art Unit:

1626 Organic Chemistry

Agent:

Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.

Inventors:

Olli TÖRMÄKANGAS; Terhi HEIKKINEN

Assignee:

Orion Corporation

Priority:

01/28/16

Filed:

07/01/19

Granted:

11/17/20

Expiration:

01/28/36

Abstract

The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.

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