US 11,130,980 B2
USE OF MONENSIN TO REGULATE GLYCOSYLATION OF RECOMBINANT PROTEINSGeneral
US 11,130,980 B2
USE OF MONENSIN TO REGULATE GLYCOSYLATION OF RECOMBINANT PROTEINS
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Michail A Belyavskyi
Art Unit:
1644 Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
Agent:
Henry P. Wu
Inventors:
Sandhya PANDE; Mirna MUJACIC
Assignee:
Priority:
10/30/14
Filed:
04/29/16
Granted:
09/28/21
Expiration:
04/06/34
Abstract
Methods of modulating high mannose glycoform content of a protein in a cell culture by contacting the cells expressing the protein of interest with monesin are provided.
Cooperative Patent Classification (CPC)
C12C12P21/005C12P