REMOVAL OF LEAKED AFFINITY PURIFICATION LIGAND

The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.

Removal of leaked affinity purification ligand

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

ORGANIC CHEMISTRY

Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies 

PEPTIDES 

Drugs for skeletal disorders-for joint disorders, e.g. arthritis, arthrosis

Drugs for dermatological disorders-Antipsoriatics

PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL

Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor-Selective adsorption, e.g. chromatography-characterised by constructional or operational features-relating to flow patterns-using two or more columns-placed in series

SEPARATION 

Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof-from animals; from humans-Receptors; Cell surface antigens; Cell surface determinants -for cytokines; for lymphokines; for interferons-for tumor necrosis factor [TNF], for lymphotoxin [LT]

Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor-Selective adsorption, e.g. chromatography-characterised by the separation mechanism-involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion-Ion-exchange-Anion-exchange

Fusion polypeptide-Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof-from animals; from humans-Receptors; Cell surface antigens; Cell surface determinants -NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154 

Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor-Selective adsorption, e.g. chromatography-characterised by the separation mechanism-involving specific interaction not covered by one or more of groups ; B01D15/265 and;  B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography-Affinity chromatography-of the antigen-antibody type, e.g. protein A, G or L chromatography

General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length-Extraction; Separation; Purification-by chromatography-Affinity chromatography or related techniques based upon selective absorption processes

General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length-Extraction; Separation; Purification-by chromatography-Ion-exchange chromatography

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