US 5,688,688 A
Vector for expression of a polypeptide in a mammalian cellGeneral
US 5,688,688 A
Vector for expression of a polypeptide in a mammalian cell
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Michael P. Woodward
Art Unit:
1643 Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
Agent:
Inventors:
PAUL A. LUCIW; DINO DINA; KATHELYN STEIMER; RAY S. PESCADOR; CARLOS GEORGE-NASCIMENTO; DEBORAH PARKES; ROB HALLEWELL; PHILIP J. BARR; MARTHA TRUETT
Assignee:
Priority:
10/31/84
Filed:
08/10/94
Granted:
11/18/97
Expiration:
11/18/17
Abstract
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.