US 6,114,319 A
Compositions containing difluprednateGeneral
US 6,114,319 A
Compositions containing difluprednate
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Zohreh Fay
Art Unit:
1614 Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
Inventors:
MASAKO KIMURA; SHIN-ICHI YASUEDA; MASAZUMI YAMAGUCHI; KATSUHIRO INADA
Assignee:
Priority:
05/14/97
Filed:
05/12/98
Granted:
09/05/00
Expiration:
05/12/18
Abstract
The present invention relates to a liquid composition comprising difluprednate, oil, water and an emulsifier. The composition of the present invention has superior antiinflammatory action and antiallergic action. The composition of the present invention shows superior transfer to a lesion and uniform drug distribution upon administration, as compared to conventional preparations containing difluprednate, so that it shows sufficient efficacy in a smaller dose. The inventive composition is associated with extremely less uncomfortable feeling and foreign sensation upon administration, as compared to conventional preparations containing difluprednate, and it can be administered easily to local sites of eye, nose, ear and the like.