US 6,417,191 B1
Synergistic combinations of zidovudine, 1592U89 and 3TCGeneral
US 6,417,191 B1
Synergistic combinations of zidovudine, 1592U89 and 3TC
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Russell Travers
Art Unit:
1617 Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
Agent:
Inventors:
DAVID WALTER BARRY; MARTHA HEIDER ST. CLAIR
Assignee:
Priority:
03/30/95
Filed:
03/28/96
Granted:
07/09/02
Expiration:
03/28/16
Abstract
The present invention relates to therapeutic combinations of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol (1592U89), 3′-azido-3′-deoxythymidine (zidovudine) and (2R,cis)-4-amino-]-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (3TC) (or, alternatively to 3TC, (2R,cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (FTC)) which have anti-HIV activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HIV infections including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.