US 6,747,002 B2
Pharmacokinetic and pharmacodynamic modeling of erythropoietin administrationGeneral
US 6,747,002 B2
Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Marjorie Moran
Art Unit:
1631 Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
Inventors:
Wing Cheung; David Gibson; Christine Cote; Els Vercammen
Assignee:
Priority:
05/11/99
Filed:
05/10/00
Granted:
06/08/04
Expiration:
05/10/20
Abstract
The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.
Cooperative Patent Classification (CPC)
A61A61P19/02A61K38/1816A61PG16H50/50G16C20/30G16H