US 6,962,940 B2
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereofGeneral
US 6,962,940 B2
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Golam M. M. Shameem
Art Unit:
1626 Organic Chemistry
Agent:
Inventors:
George W. Muller; Peter H. Schafer; Hon-Wah Man; Chuansheng Ge
Assignee:
Priority:
03/20/02
Filed:
03/19/03
Granted:
11/08/05
Expiration:
03/20/22
Abstract
Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
Cooperative Patent Classification (CPC)
A61A61P19/00A61K31/4035A61PC07B2200/07C07C317/28C07D209/48C07BY02A50/30Y02A