US 7,009,034 B2
Biocompatible crosslinked polymersGeneral
US 7,009,034 B2
Biocompatible crosslinked polymers
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Jon Weber
Art Unit:
1654 Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzyme
Inventors:
Chandrashekhar P. Pathak; Amarpreet S. Sawhney; Peter G. Edelman
Assignee:
Priority:
09/23/96
Filed:
11/09/01
Granted:
03/07/06
Expiration:
11/14/17
Abstract
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
Cooperative Patent Classification (CPC)
A61A61L24/106A61K9/0014A61LC08G63/912C08L2666/02C08GG06K2207/1016G06KC07K14/75C07K