US 7,332,277 B2
Methods for detection of genetic disordersGeneral
US 7,332,277 B2
Methods for detection of genetic disorders
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Ethan Whisenant
Art Unit:
1634 Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
Agent:
Inventors:
Ravinder S. Dhallan
Assignee:
Priority:
03/01/02
Filed:
09/11/03
Granted:
02/19/08
Expiration:
03/03/23
Abstract
The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.
Cooperative Patent Classification (CPC)
C12C12Q2531/113C12Q