US 07,737,112 B2 | Composition for enzyme inhibition

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US 07,737,112 B2

Composition for enzyme inhibition

Tech Center:

1654 Biotechnology and Organic Chemistry

Examiner:

David Lukton

Art Unit:

1654 Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzyme

Agent:

Ropes & Gray LLP

Inventors:

Evan R. Lewis; Mark Nguyen Ho; Fabiana N. Fonseca

Assignee:

Onyx Therapeutics, Inc.

Priority:

12/07/04

Filed:

12/07/05

Granted:

06/15/10

Expiration:

12/19/26

Abstract

Compositions comprising one or more practically insoluble proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin, substantially increase the solubility of these proteasome inhibitors and facilitate their administration. Such compositions optionally comprise a buffer. Methods of treatment using such compositions are also disclosed.

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