US 7,928,205 B2
METHODS FOR REFOLDING OF RECOMBINANT ANTIBODIESGeneral
US 7,928,205 B2
METHODS FOR REFOLDING OF RECOMBINANT ANTIBODIES
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
David A Saunders
Art Unit:
1644 Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
Agent:
Charles K. Sholtz
Inventors:
Thomas Dillon; Douglas Rehder; Pavel Bondarenko; Margaret Ricci; Himanshu S. Gadgil; Douglas Banks; Joe Zhou; Yuefeng Lu; Andrew Goetze; Yuling Zhang
Assignee:
Priority:
10/21/05
Filed:
10/21/05
Granted:
04/19/11
Expiration:
02/13/26
Abstract
The present invention is generally directed to methods of producing an increase in the enrichment or recovery of preferred forms of IgG proteins. More particularly, the invention relates to subjecting preparations of such recombinant IgG proteins with a reduction/oxidation coupling reagent and optionally a chaotropic agent.
Cooperative Patent Classification (CPC)
C07C07K2317/55C07KA61K39/39525A61P37/00A61K