US 8,193,196 B2
Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparationsGeneral
US 8,193,196 B2
Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Bruck Kifle
Art Unit:
1622 Organic Chemistry
Agent:
Inventors:
Giuseppe Claudio Viscomi; Manuela Campana; Donatella Confortini; Maria Miriam Barbanti; Dario Braga
Assignee:
Priority:
03/03/05
Filed:
02/27/06
Granted:
06/05/12
Expiration:
09/02/27
Abstract
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
Cooperative Patent Classification (CPC)
C07C07D498/22C07B2200/13C07DA61K31/437A61P31/04A61K