US 08,557,283 B2
Controlled release formulations of levodopa and uses thereofGeneral
US 08,557,283 B2
Controlled release formulations of levodopa and uses thereof
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
San-Ming Hui
Art Unit:
1629 Organic Chemistry
Agent:
Inventors:
Ann Hsu; Jim H. Kou; Laman Lynn Alani
Assignee:
Priority:
12/28/07
Filed:
12/11/12
Granted:
10/15/13
Expiration:
12/28/27
Abstract
The current invention provides a controlled release oral solid formulation of levodopa comprising levodopa, a decarboxylase inhibitor, and a carboxylic acid. Also provided by this invention is multiparticulate, controlled release oral solid formulations of levodopa comprising: i) a controlled release component comprising a mixture of levodopa, a decarboxylase inhibitor and a rate controlling excipient; ii) a carboxylic acid component; and iii) an immediate release component comprising a mixture of levodopa and a decarboxylase inhibitor.
Cooperative Patent Classification (CPC)
A61A61K2300/00A61P25/18A61KC07C229/36C07C