Treatment for diabetes in patients inappropriate for metformin therapy

The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients for whom metformin therapy is inappropriate due to intolerability or contraindication against metformin.

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil-not condensed and containing further heterocyclic rings, e.g. cromakalim

PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES 

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyridazines; Hydrogenated pyridazines-ortho- or peri-condensed with heterocyclic ring systems

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole-Oxazoles-not condensed and containing further heterocyclic rings

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Medicinal preparations characterised by special physical form -Galenical forms characterised by the site of application-Mouth and digestive tract, i.e. intraoral and peroral administration 

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil-condensed with carbocyclic rings, e.g. carbazole

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole-Thiazoles-not condensed and containing further heterocyclic rings

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with one nitrogen as the only ring hetero atom-Non condensed pyridines; Hydrogenated derivatives thereof-containing further heterocyclic ring systems-containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole 

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with one nitrogen as the only ring hetero atom-ortho- or peri-condensed with heterocyclic ring systems-the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine

Medicinal preparations containing peptides -Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof -from animals; from humans -Hormones -Insulins

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim-ortho- or peri-condensed with heterocyclic rings-Purines, e.g. adenine-having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir

Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00-Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Medicinal preparations containing peptides -Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof -from animals; from humans -Hormones -Glucagons

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Drugs for disorders of the metabolism -for glucose homeostasis -for hyperglycaemia, e.g. antidiabetics

SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim-having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim-not condensed and containing further heterocyclic rings

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