US 8,877,776 B2
(L)-MALATE SALT OF N-(4-{[6,7-BIS(METHYLOXY) QUINOLIN-4-Y1]OXY}PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDEGeneral
US 8,877,776 B2
(L)-MALATE SALT OF N-(4-{[6,7-BIS(METHYLOXY) QUINOLIN-4-Y1]OXY}PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Kendra D Carter
Art Unit:
1627 Organic Chemistry
Inventors:
Adrian St. Clair Brown; William P. Gallagher; Peter Lamb
Assignee:
Priority:
10/20/11
Filed:
10/20/11
Granted:
11/04/14
Expiration:
10/09/29
Abstract
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane -1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-ffuorophenyl)cyclopropane-1,1-dicarboxamide.
Cooperative Patent Classification (CPC)
A61A61P25/00A61PC07D215/233C07D