Device and method for pressure-driven plug transport and reaction

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING

Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such compositions-involving hydrolase-involving esterase

MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS ; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

MEASURING; TESTING

Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials-Investigating individual particles-Optical investigation techniques, e.g. flow cytometry-Handling flow, e.g. hydrodynamic focusing

INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES 

PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Control aspects-Sensing operations-Type of sensors-Optical sensors-Infrared light

CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS

TECHNICAL SUBJECTS COVERED BY FORMER USPC

Chemistry: analytical and immunological testing-including sample preparation-Volumetric liquid transfer

TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

Flow mixers; Mixers for falling materials, e.g. solid particles -Static mixers -in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions-Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction-Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles

MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING 

Moving or stopping fluids-Moving fluids with specific forces or mechanical means-specific forces-thermal energy, e.g. vaporisation, bubble jet-Marangoni flow; Thermocapillary effect

CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Additional features-Microreactors placed in series, on the same or on different supports

Moving or stopping fluids-Moving fluids with specific forces or mechanical means-specific mechanical means and fluid pressure-fluid pressure, pneumatics

Flow mixers; Mixers for falling materials, e.g. solid particles -Static mixers -in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions-Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction-Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles-Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow

Mixing according to the phases to be mixed, e.g. dispersing or emulsifying-Mixing liquids with liquids; Emulsifying-using flow mixing

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Type of compounds synthesised-Organic compounds-Peptides

Solutions for specific problems relating to chemical or physical laboratory apparatus-Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept

Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor-using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Additional features-Microreactors placed in parallel, on the same or on different supports

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Apparatus-Means for coding or tagging the apparatus or the reagents-Chemical means-fluorophore

Other mixers; Mixing plants; Combinations of mixers-Micromixers-the materials to be mixed flowing in the form of droplets-the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets

Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials-Investigating individual particles-Optical investigation techniques, e.g. flow cytometry-microstructural devices

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Features relative to the processes being carried out-Sequential processes

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Features relative to the processes being carried out-Solution-phase processes

Solutions for specific problems relating to chemical or physical laboratory apparatus-Fluid handling related problems-Handling of plugs of fluid surrounded by immiscible fluid

Solutions for specific problems relating to chemical or physical laboratory apparatus-Fluid handling related problems-Handling flowable solids, e.g. microscopic beads, cells, particles-Trapping microscopic beads

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Type of compounds synthesised-Organic compounds-Biological products

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Feeding or evacuation

Additional constructional details-Geometry, shape and general structure-Configuration of multiple channels and/or chambers in a single devices-Multiple inlets and one sample wells, e.g. mixing, dilution

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Features relative to the processes being carried out-Parallel processes

Moving or stopping fluids-Moving fluids with specific forces or mechanical means-specific forces-radiation pressure, optical tweezers

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Control aspects-Sensing operations-Type of sensors-Optical sensors-Ultraviolet light

Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers-Containers for the purpose of retaining a material to be analysed, e.g. test tubes -with fluid transport, e.g. in multi-compartment structures -by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip -characterised by the means for controlling flow resistance, e.g. flow controllers, baffles 

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Materials of construction-comprising coatings other than catalytically active coatings

Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials-Investigating individual particles-Optical investigation techniques, e.g. flow cytometry-Handling flow, e.g. hydrodynamic focusing-Handling samples, e.g. injecting samples

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Additional features-Aspects relating to the size of the reactor-Dimensions of the flow channels

TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE

Technologies having an indirect contribution to adaptation to climate change-Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

Heating or cooling apparatus ; Heat insulating devices-with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples 

Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor-using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis-Flow Injection Analysis

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Mixing

Preparation of compounds containing saccharide radicals -Preparation of nitrogen-containing carbohydrates-N-glycosides-Nucleotides-Polynucleotides, e.g. nucleic acids, oligoribonucleotides

FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE 

Solutions for specific problems relating to chemical or physical laboratory apparatus-Fluid handling related problems-Handling flowable solids, e.g. microscopic beads, cells, particles

Mixing characterised by the nature of the mixed materials or by the application field-Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Type of compounds synthesised-Organic compounds-Nucleotides

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Type of compounds synthesised-Compositions, e.g. coatings, crystals, formulations

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays 

Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers-Containers for the purpose of retaining a material to be analysed, e.g. test tubes -with fluid transport, e.g. in multi-compartment structures -by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip -characterised by multiphase flow arrangements-specially adapted for droplet or plug flow, e.g. digital microfluidics 

Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers-Containers for the purpose of retaining a material to be analysed, e.g. test tubes -with fluid transport, e.g. in multi-compartment structures -by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip -specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules 

Moving or stopping fluids-Moving fluids with specific forces or mechanical means-specific forces-electrical forces, e.g. electrokinetic-Dielectrophoretic forces

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Aspects relating to microreactors-Laminate assemblies, i.e. the reactor comprising a stack of plates

Flow mixers; Mixers for falling materials, e.g. solid particles -Injector mixers -in conduits or tubes through which the main component flows

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Microreactors, e.g. miniaturised or microfabricated reactors 

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Apparatus-Features relating to reactor vessels-Individual reactor vessels-Reactor vessels with top and bottom openings

NANOTECHNOLOGY

Nanotechnology for materials or surface science, e.g. nanocomposites

SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES

Chemistry: analytical and immunological testing-Condition responsive control

Chemistry: analytical and immunological testing-Automated chemical analysis-with a continuously flowing sample or carrier stream-with formation of a segmented stream

Additional constructional details-Geometry, shape and general structure-Configuration of multiple channels and/or chambers in a single devices-Serpentine channels

Chemical, physical or physico-chemical processes in general; Their relevant apparatus-Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology-Type of compounds synthesised-Organic compounds-Non-biologic macromolecules, e.g. polymeric compounds

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