DIPEPTIDES TO ENHANCE YIELD AND VIABILITY FROM CELL CULTURES

The present invention relates to the culture of animal cells in serum-free culture medium. The present invention provides particular dipeptides that can improve recombinant protein production and cell viability in such cultures, especially in the absence of peptones.

Dipeptides to enhance yield and viability from cell cultures

BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING

Specific components of cell culture medium-Organic components-Amino acids

MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA 

ORGANIC CHEMISTRY

Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof-containing only normal peptide links-Dipeptides-with the first amino acid being neutral-and aliphatic-the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr

PEPTIDES 

Active agents used in cell culture processes, e.g. differentation-Growth factors-Insulin-like growth factors [IGF]

Active agents used in cell culture processes, e.g. differentation-Proteins not provided for elsewhere

Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies 

Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof-containing only normal peptide links-Dipeptides-with the first amino acid being acidic

Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor; -Culture media for cell or tissue culture -Serum-free medium, which may still contain naturally-sourced components

Genetically modified cells-Cells for production

Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof-containing only normal peptide links-Dipeptides-with the first amino acid being neutral-and aromatic or cycloaliphatic

Immunoglobulins specific features-characterized by their source of isolation or production-Specific host cells or culture conditions, e.g. components, pH or temperature

Specific components of cell culture medium-Organic components-Amines, e.g. putrescine

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