Nasal drug products and methods of their use

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Drugs for disorders of the muscular or neuromuscular system

SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Drugs for disorders of the nervous system

Drugs for disorders of the nervous system-Centrally acting analgesics, e.g. opioids

Drugs for disorders of the blood or the extracellular fluid

Drugs for disorders of the nervous system-for treating abuse or dependence-Opioid-abuse

Drugs for disorders of the alimentary tract or the digestive system-for nausea, cinetosis or vertigo; Antiemetics

Drugs for disorders of the respiratory system

Drugs for disorders of the cardiovascular system-Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Inhalators -Inhaling devices inserted into the nose

DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY ; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY ; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR 

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with one nitrogen as the only ring hetero atom-Quinolines; Isoquinolines-Morphinan derivatives, e.g. morphine, codeine

PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES 

Sprayers or atomisers specially adapted for therapeutic purposes -operated by applying mechanical pressure to the liquid to be sprayed or atomised

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-Inorganic compounds

Drugs for disorders of the respiratory system-Central respiratory analeptics

Medicinal preparations characterised by special physical form -Solutions 

Drugs for disorders of the nervous system-for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Medicinal preparations characterised by special physical form -Galenical forms characterised by the site of application-Nose

Sprayers or atomisers specially adapted for therapeutic purposes -operated by air ; or other gas;  pressure applied to the liquid ; or other product;  to be sprayed or atomised 

Devices for introducing or retaining media, e.g. remedies, in cavities of the body 

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite-containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates-Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids-Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide

Drugs for disorders of the nervous system-Hypnotics; Sedatives

Drugs for disorders of the cardiovascular system

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite-containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates-Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids-Amino acids, e.g. glycine, EDTA or aspartame

Drugs for disorders of the senses-Ophthalmic agents

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