Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates

A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-II, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having oxygen as the only ring hetero atom, e.g. fungichromin-having six-membered rings with one oxygen as the only ring hetero atom-not condensed with another ring

PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES 

Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics-Antivirals-for RNA viruses-for HIV

ORGANIC CHEMISTRY

Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members-having three double bonds between ring members or between ring members and non-ring members-having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom-with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms-Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals-Amides; Imides

HETEROCYCLIC COMPOUNDS 

Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00-in which the condensed systems contains four or more hetero rings

Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members-having three double bonds between ring members or between ring members and non-ring members-having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom-with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms-Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals-Acids; Esters-Processes of preparation

Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00-in which the condensed system contains four or more hetero rings

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with one nitrogen as the only ring hetero atom-Non condensed pyridines; Hydrogenated derivatives thereof-having oxo groups directly attached to the heterocyclic ring

TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE

Technologies relating to chemical industry-Improvements relating to the production of bulk chemicals-Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms -in which the condensed system contains three hetero rings-Ortho-condensed systems

Prosecution History analysis

Examiner Search analysis

Invalidity Framework analysis

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