Conjugation process of bacterial polysaccharides to carrier proteins

Process for conjugation of bacterial saccharides including Streptococcus pneumoniae and Haemophilus influenzae saccharides by reductive amination are provided herein.

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics-Antibacterial agents

SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Medicinal preparations containing antigens or antibodies -Bacterial antigens-Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus; , streptococcus-Streptococcus

PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES 

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates-the non-active ingredient being a modifying agent-the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule-the organic macromolecular compound being a polysaccharide or a derivative thereof

Medicinal preparations containing antigens or antibodies -characterised by the link between antigen and carrier

Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics-Antivirals-for RNA viruses-for influenza or rhinoviruses

Medicinal preparations containing antigens or antibodies -characteristics by the carrier linked to the antigen-Proteins-Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates-the non-active ingredient being a modifying agent-the modifying agent being a protein, peptide or polyamino acid-Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent -the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates-the non-active ingredient being a modifying agent-the modifying agent being a protein, peptide or polyamino acid-Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent -Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins

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