CARBOHYDRATE PHOSPHONATE DERIVATIVES AS MODULATORS OF GLYCOSYLATION

Compounds of Formula (I) are useful as modulators of glycosylation. Compounds of Formula (I) have the following structure: (I) and the definitions of the other variables are provided herein.

Carbohydrate phosphonate derivatives as modulators of glycosylation

BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING

Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor; -Animal cells or tissues; Human cells or tissues -Vertebrate cells-Embryonic cells ; ; Embryoid bodies

MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA 

ORGANIC CHEMISTRY

Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings-having no double bonds between ring members or between ring members and non-ring members-with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms-Oxygen atoms

HETEROCYCLIC COMPOUNDS 

Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond-Acyclic radicals

SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS 

Genetically modified cells

Active agents used in cell culture processes, e.g. differentation-Small molecules not provided for elsewhere

Immunoglobulins specific features-characterized by their source of isolation or production-Specific host cells or culture conditions, e.g. components, pH or temperature

PEPTIDES 

Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings-having no double bonds between ring members or between ring members and non-ring members-with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms-Nitrogen atoms not forming part of a nitro radical

Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies -against material from animals or humans-against receptors, cell surface antigens or cell surface determinants-against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154 

Immunoglobulins specific features-characterized by post-translational modification-Glycosylation, sialylation, or fucosylation

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