METHODS FOR MODULATING MANNOSE CONTENT OF RECOMBINANT PROTEINS

The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

Methods for modulating mannose content of recombinant proteins

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Drugs for disorders of the alimentary tract or the digestive system-for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Drugs for disorders of the alimentary tract or the digestive system-for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING

Specific components of cell culture medium-Organic components-Amino acids

MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA 

Medicinal preparations containing antigens or antibodies -comprising antibodies

PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES 

Specific components of cell culture medium-Organic components-Sugars

Drugs for disorders of the nervous system

Drugs for dermatological disorders-Antipsoriatics

ORGANIC CHEMISTRY

Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies -against material from animals or humans-against cytokines, lymphokines or interferons-Interleukins [IL]

PEPTIDES 

Drugs for skeletal disorders-for joint disorders, e.g. arthritis, arthrosis

Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies 

Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Drugs for disorders of the nervous system-for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Antineoplastic agents-specific for leukemia

Drugs for disorders of the respiratory system

Specific components of cell culture medium-Organic components-Vitamins

Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor; -Culture media for cell or tissue culture -Serum-free medium, which may still contain naturally-sourced components

Drugs for genital or sexual disorders ; Contraceptives-Antiabortive agents; Labour repressants

Drugs for disorders of the senses-Ophthalmic agents

Drugs for skeletal disorders-for non-specific disorders of the connective tissue

Preparation of peptides or proteins -Glycopeptides, glycoproteins

FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE 

Immunoglobulins specific features-characterized by post-translational modification-Glycosylation, sialylation, or fucosylation

Immunoglobulins specific features-characterized by immunoglobulin fragments-variable (Fv) region, i.e. VH and/or VL

Specific components of cell culture medium-Buffer, e.g. pH regulation, osmotic pressure

Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Specific components of cell culture medium-Undefined extracts-from plants

Immunoglobulins specific features-characterized by taxonomic origin-from primates, e.g. man

Drugs for immunological or allergic disorders-Antiallergic agents 

Drugs for disorders of the cardiovascular system

Drugs for dermatological disorders

Immunoglobulins specific features-characterized by effect upon binding to a cell or to an antigen-Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Specific components of cell culture medium-Undefined extracts-from fungi, e.g. yeasts

Antineoplastic agents

Specific components of cell culture medium-Atmosphere, e.g. low oxygen conditions

Drugs for disorders of the blood or the extracellular fluid

Immunoglobulins specific features-characterized by immunoglobulin fragments-variable (Fv) region, i.e. VH and/or VL-Complementarity determining region [CDR]

Drugs for immunological or allergic disorders-Immunomodulators-Immunosuppressants, e.g. drugs for graft rejection

Specific components of cell culture medium-Inorganic components-Metals; Metal chelators-Light metals, i.e. alkali, alkaline earth, Be, Al, Mg

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