US 9,382,220 B2
Methods of synthesis and/or purification of diaminophenothiazinium compoundsGeneral
US 9,382,220 B2
Methods of synthesis and/or purification of diaminophenothiazinium compounds
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Kahsay Habte
Art Unit:
1624 Organic Chemistry
Agent:
Inventors:
Claude Michel WISCHIK; John Mervyn David STOREY; Colin MARSHALL; James Peter SINCLAIR; Thomas Craven BADDELEY
Assignee:
Priority:
07/11/06
Filed:
05/09/13
Granted:
07/05/16
Expiration:
07/11/26
Abstract
Described are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue), the resulting (high purity) compounds, compositions comprising such compounds (e.g., tablets, capsules), and the use of such high purity compounds. The compounds are useful in inactivating pathogens, and methods of medical treatment, prophylaxis, and diagnosis of diseases including a tauopathy, related neurological and infectious diseases.
Cooperative Patent Classification (CPC)
A61A61P31/12A61K31/5415A61PC09B67/0096C09BY02A50/30Y02AC07D279/20C07D