Treatment for diabetes in patients inappropriate for metformin therapy

The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients for whom metformin therapy is inappropriate due to intolerability or contraindication against metformin.

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES 

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil-condensed with carbocyclic rings, e.g. carbazole

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim-ortho- or peri-condensed with heterocyclic rings-Purines, e.g. adenine-having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir

Medicinal preparations characterised by special physical form -Galenical forms characterised by the site of application-Mouth and digestive tract, i.e. intraoral and peroral administration 

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim-not condensed and containing further heterocyclic rings

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil-not condensed and containing further heterocyclic rings, e.g. cromakalim

Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole-Thiazoles-not condensed and containing further heterocyclic rings

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with one nitrogen as the only ring hetero atom-ortho- or peri-condensed with heterocyclic ring systems-the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyridazines; Hydrogenated pyridazines-ortho- or peri-condensed with heterocyclic ring systems

Drugs for disorders of the metabolism 

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with one nitrogen as the only ring hetero atom-Non condensed pyridines; Hydrogenated derivatives thereof-containing further heterocyclic ring systems-containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole 

Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00-Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with two ; or more;  nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines-Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim-having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

Drugs for disorders of the metabolism -for glucose homeostasis -for hyperglycaemia, e.g. antidiabetics

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole-Oxazoles-not condensed and containing further heterocyclic rings

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