US 9,527,833 B2 | Stable crystal form of tipiracil hydrochloride and crystallization method for the same

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US 9,527,833 B2

Stable crystal form of tipiracil hydrochloride and crystallization method for the same

Tech Center:

1600 Biotechnology and Organic Chemistry

Examiner:

Dennis Heyer

Art Unit:

1628 Organic Chemistry

Agent:

Wenderoth, Lind & Ponack, L.L.P.

Inventors:

Hideki KAZUNO; Tomonobu MUTSUMI

Assignee:

TAIHO PHARMACEUTICAL CO., LTD.

Priority:

06/17/13

Filed:

06/17/14

Granted:

12/27/16

Expiration:

06/17/34

Abstract

An objective of the present invention is to obtain a stable crystal form of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride. The present invention provides a crystal of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride exhibiting characteristic peaks at angles of 11.6°, 17.2°, 17.8°, 23.3°, 27.1°, and 29.3° as a diffraction angle (2θ±0.1°) in powder X-ray diffraction.

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