US 09,533,046 B2
Controlled release formulations of levodopa and uses thereofGeneral
US 09,533,046 B2
Controlled release formulations of levodopa and uses thereof
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
San-Ming Hui
Art Unit:
1621 Organic Chemistry
Agent:
Inventors:
Ann Hsu; Jim Kou; Laman Alani
Assignee:
Priority:
12/28/07
Filed:
12/04/15
Granted:
01/03/17
Expiration:
12/28/27
Abstract
The current invention provides a controlled release oral solid formulation of levodopa comprising levodopa, a decarboxylase inhibitor, and a carboxylic acid. Also provided by this invention is multiparticulate, controlled release oral solid formulations of levodopa comprising: i) a controlled release component comprising a mixture of levodopa, a decarboxylase inhibitor and a rate controlling excipient; ii) a carboxylic acid component; and iii) an immediate release component comprising a mixture of levodopa and a decarboxylase inhibitor.
Cooperative Patent Classification (CPC)
A61A61K2300/00A61P25/28A61KC07C229/36C07C