US 9,643,997 B2
Capture purification processes for proteins expressed in a non-mammalian system
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US 9,643,997 B2
Capture purification processes for proteins expressed in a non-mammalian system
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Brian J Gangle
Art Unit:
1645 Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
Agent:
Raymond M. Doss
Inventors:
Joseph Edward SHULTZ; Roger HART
Assignee:
AMGEN INC.
Priority:
06/25/09
Filed:
01/16/15
Granted:
05/09/17
Expiration:
06/25/29
Abstract
Methods of purifying proteins expressed in non-mammalian expression systems in a non-native soluble form directly from cell lysate are disclosed. Methods of purifying proteins expressed in non-mammalian expression systems in a non-native limited solubility form directly from a refold solution are also disclosed. Resin regeneration methods are also provided.
Cooperative Patent Classification (CPC)
C07C07K16/00C07K

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