US 9,724,330 B2
Methods of using (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dioneGeneral
US 9,724,330 B2
Methods of using (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Golam M M Shameem
Art Unit:
1626 Organic Chemistry
Agent:
Inventors:
George W. MULLER; Hon-Wah MAN; Peter H. SCHAFER; Chuansheng GE
Assignee:
Priority:
03/20/02
Filed:
02/05/16
Granted:
08/08/17
Expiration:
03/20/22
Abstract
Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
Cooperative Patent Classification (CPC)
A61A61P17/04A61K31/4035A61PY02A50/30Y02AC07B2200/07C07C317/28C07D209/48C07B