Nasal drug products and methods of their use

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

MEDICAL OR VETERINARY SCIENCE; HYGIENE

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-Inorganic compounds

PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES 

Anatomical parts of the body-Head-Nose

DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY ; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY ; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR 

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite-containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates-Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids-Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide

Medicinal preparations characterised by special physical form -Galenical forms characterised by the site of application-Nose

Devices for introducing or retaining media, e.g. remedies, in cavities of the body 

Inhalators -Inhaling devices inserted into the nose

General characteristics of the apparatus-Constructional features of carpules, syringes or blisters

Sprayers or atomisers specially adapted for therapeutic purposes -Particle size control

Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient-Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite-containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates-Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids-Amino acids, e.g. glycine, EDTA or aspartame

Sprayers or atomisers specially adapted for therapeutic purposes -operated by applying mechanical pressure to the liquid to be sprayed or atomised-Syringe-type or piston-type sprayers or atomisers

Sprayers or atomisers specially adapted for therapeutic purposes -operated by applying mechanical pressure to the liquid to be sprayed or atomised

Medicinal preparations containing organic active ingredients-Heterocyclic compounds-having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins-having six-membered rings with one nitrogen as the only ring hetero atom-Quinolines; Isoquinolines-Morphinan derivatives, e.g. morphine, codeine

Medicinal preparations characterised by special physical form -Solutions 

General characteristics of the apparatus-having air pumping means-hand operated-Syringe, piston type

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