US RE048,267 E1
Variants of C-Type Natriuretic PeptideGeneral
US RE048,267 E1
Variants of C-Type Natriuretic Peptide
Tech Center:
3900 Reexam/Abandonments
Examiner:
Bruce R Campell
Art Unit:
3991 Central Reexamination Unit
Inventors:
Daniel J. Wendt; Shinong Long; Sianna Castillo; Christopher P. Price; Mika Aoyagi-Scharber; Michel Claude Vellard; Augustus O. Okhamafe
Assignee:
Priority:
07/11/17
Filed:
07/11/17
Granted:
10/20/20
Expiration:
07/11/37
Abstract
The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).