US 8,835,113 B2
Methods and compositions for assaying a sample for an aggregantGeneral
US 8,835,113 B2
Methods and compositions for assaying a sample for an aggregant
Tech Center:
1600 Biotechnology and Organic Chemistry
Examiner:
Kenneth Horlick
Art Unit:
1637 Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
Inventors:
Bin Liu; Guillermo C. Bazan
Priority:
01/31/05
Filed:
09/03/13
Granted:
09/16/14
Expiration:
01/31/25
Abstract
This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.
Cooperative Patent Classification (CPC)
C08C08G61/123C08GC12Q2565/101C12QY10T436/143333Y10TG01N33/54373G01N